Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

Influenza virus polymerase initiates the biosynthesis of its own mRNAs with capped 10- to 13-nucleotide fragments cleaved from cellular (pre-)mRNAs. Two activities are required for this cap-snatching activity: specific binding of the cap structure and an endonuclease activity. Recent work has shown...

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Detalhes bibliográficos
Main Authors: Crépin, Thibaut, Dias, Alexandre, Palencia, Andrés, Swale, Christopher, Cusack, Stephen, Ruigrok, Rob W. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937609/
https://ncbi.nlm.nih.gov/pubmed/20592097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00995-10
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