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Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

Understanding how avian influenza viruses adapt to human hosts is critical for the monitoring and prevention of future pandemics. Host specificity is determined by multiple sites in different viral proteins, and mutation of only a limited number of these sites can lead to inter-species transmission....

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Detalhes bibliográficos
Main Authors: Tarendeau, Franck, Crepin, Thibaut, Guilligay, Delphine, Ruigrok, Rob W. H., Cusack, Stephen, Hart, Darren J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515345/
https://ncbi.nlm.nih.gov/pubmed/18769709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000136
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