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Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

Understanding how avian influenza viruses adapt to human hosts is critical for the monitoring and prevention of future pandemics. Host specificity is determined by multiple sites in different viral proteins, and mutation of only a limited number of these sites can lead to inter-species transmission....

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Autors principals: Tarendeau, Franck, Crepin, Thibaut, Guilligay, Delphine, Ruigrok, Rob W. H., Cusack, Stephen, Hart, Darren J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515345/
https://ncbi.nlm.nih.gov/pubmed/18769709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000136
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