Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase Cap-Snatching Domains

Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10–13 nucleotides from the 5′ cap by the PA subunit endonucl...

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Detalhes bibliográficos
Main Authors: Guilligay, Delphine, Kadlec, Jan, Crépin, Thibaut, Lunardi, Thomas, Bouvier, Denis, Kochs, Georg, Ruigrok, Rob W. H., Cusack, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893164/
https://ncbi.nlm.nih.gov/pubmed/24454773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084973
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