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Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding

The RNA-dependent RNA polymerase of influenza virus is a heterotrimer formed by the PB1, PB2, and PA subunits. Although PA is known to be required for polymerase activity, its precise role is still unclear. Here, we investigated the function of the N-terminal region of PA. Protease digestion of puri...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hara, Koyu, Schmidt, Florian I., Crow, Mandy, Brownlee, George G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2006
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563815/
https://ncbi.nlm.nih.gov/pubmed/16873236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00600-06
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