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Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding

The RNA-dependent RNA polymerase of influenza virus is a heterotrimer formed by the PB1, PB2, and PA subunits. Although PA is known to be required for polymerase activity, its precise role is still unclear. Here, we investigated the function of the N-terminal region of PA. Protease digestion of puri...

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Bibliografiske detaljer
Main Authors: Hara, Koyu, Schmidt, Florian I., Crow, Mandy, Brownlee, George G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563815/
https://ncbi.nlm.nih.gov/pubmed/16873236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00600-06
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