PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

The 2009 pandemic influenza virus (pH1N1) is a swine-origin reassortant containing human, avian, and swine influenza genes. We have previously shown that the polymerase complex of the pH1N1 strain A/California/04/2009 (Cal) is highly active in mammalian 293T cells, despite the avian origin of both i...

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Bibliographic Details
Main Authors: Bussey, Kendra A., Desmet, Emily A., Mattiacio, Jonelle L., Hamilton, Alice, Bradel-Tretheway, Birgit, Bussey, Howard E., Kim, Baek, Dewhurst, Stephen, Takimoto, Toru
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126589/
https://ncbi.nlm.nih.gov/pubmed/21561908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00522-11
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