The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit

Influenza A virus (IAV) replicates in the upper respiratory tract of humans at 33 °C and in the intestinal tract of birds at close to 41 °C. The viral RNA polymerase complex comprises three subunits (PA, PB1 and PB2) and plays an important role in host adaptation. We therefore developed an in vitro...

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Detalhes bibliográficos
Main Authors: Bradel-Tretheway, Birgit G., Kelley, Z., Chakraborty-Sett, Shikha, Takimoto, Toru, Kim, Baek, Dewhurst, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2008
Assuntos:
Jgv Direct
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067610/
https://ncbi.nlm.nih.gov/pubmed/19008377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.2008/006254-0
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