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Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex

Most avian influenza A viruses, which preferentially replicate at the high temperatures found in the digestive tract of birds, have a glutamic acid at residue 627 of the viral RNA polymerase PB2 subunit (Glu-627), whereas the human viruses, which optimally replicate at the low temperatures observed...

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Bibliografiske detaljer
Main Authors: Aggarwal, Shilpa, Dewhurst, Stephen, Takimoto, Toru, Kim, Baek
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186381/
https://ncbi.nlm.nih.gov/pubmed/21816827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262048
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