Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

The ribonucleoprotein (RNP) complex is the essential transcription-replication machinery of the influenza virus. It is composed of the trimeric polymerase (PA, PB1 and PB2), nucleoprotein (NP) and RNA. Elucidating the molecular mechanisms of RNP assembly is central to our understanding of the contro...

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Bibliografiset tiedot
Päätekijät: Andy Ka-Leung Ng, Wai-Hon Chan, Sze-Ting Choi, Mandy Ka-Han Lam, Kwok-Fai Lau, Paul Kay-Sheung Chan, Shannon Wing-Ngor Au, Ervin Fodor, Pang-Chui Shaw
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science (PLoS) 2012-01-01
Sarja:PLoS ONE
Linkit:http://europepmc.org/articles/PMC3343083?pdf=render
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