Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein

The influenza virus RNA genome is transcribed and replicated in the context of the viral ribonucleoprotein (vRNP) complex by the viral RNA polymerase. The nucleoprotein (NP) is the structural component of the vRNP providing a scaffold for the viral RNA. In the vRNP as well as during transcription an...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hsia, Ho-Pan, Yang, Yin-Hua, Szeto, Wun-Chung, Nilsson, Benjamin E., Lo, Chun-Yeung, Ng, Andy Ka-Leung, Fodor, Ervin, Shaw, Pang-Chui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770049/
https://ncbi.nlm.nih.gov/pubmed/29338047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191226
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