Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein

The influenza virus RNA genome is transcribed and replicated in the context of the viral ribonucleoprotein (vRNP) complex by the viral RNA polymerase. The nucleoprotein (NP) is the structural component of the vRNP providing a scaffold for the viral RNA. In the vRNP as well as during transcription an...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hsia, Ho-Pan, Yang, Yin-Hua, Szeto, Wun-Chung, Nilsson, Benjamin E., Lo, Chun-Yeung, Ng, Andy Ka-Leung, Fodor, Ervin, Shaw, Pang-Chui
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770049/
https://ncbi.nlm.nih.gov/pubmed/29338047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191226
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