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Hyper telomere recombination accelerates replicative senescence and may promote premature aging
Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellula...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936608/ https://ncbi.nlm.nih.gov/pubmed/20798040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006338107 |
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