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Persistent telomere cohesion protects aged cells from premature senescence
Human telomeres are bound by the telomere repeat binding proteins TRF1 and TRF2. Telomere shortening in human cells leads to a DNA damage response that signals replicative senescence. While insufficient loading of TRF2 at shortened telomeres contributes to the DNA damage response in senescence, the...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335080/ https://ncbi.nlm.nih.gov/pubmed/32620872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17133-4 |
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