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Hyper telomere recombination accelerates replicative senescence and may promote premature aging
Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellula...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936608/ https://ncbi.nlm.nih.gov/pubmed/20798040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006338107 |
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