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Hyper telomere recombination accelerates replicative senescence and may promote premature aging

Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellula...

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Autori principali: Hagelstrom, R. Tanner, Blagoev, Krastan B., Niedernhofer, Laura J., Goodwin, Edwin H., Bailey, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936608/
https://ncbi.nlm.nih.gov/pubmed/20798040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006338107
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