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Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells
For cells on the path to carcinogenesis, the key to unlimited growth potential lies in overcoming the steady loss of telomeric sequence commonly referred to as the ‘end-replication problem’ that occurs with each cell division. Most human tumors have reactivated telomerase, a specialized reverse tran...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC484178/ https://ncbi.nlm.nih.gov/pubmed/15258249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh691 |
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