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Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y(6) Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications
The P2Y(6) receptor is a cytoprotective G protein-coupled receptor (GPCR) activated by UDP (EC(50), 0.30 μM). We compared and combined modifications to enhance P2Y(6) receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifications...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2010
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935147/ https://ncbi.nlm.nih.gov/pubmed/20446735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100287t |
| Tagiau: |
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