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NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

NAD(P)H oxidases (Noxs) produce O(2)(−) and play an important role in cardiovascular pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes. To elucidate the function of endogenous Nox4 in the heart, we generated cardiac-specific Nox4(−/−) (c-Nox4(−/−)) mice...

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Bibliographische Detailangaben
Hauptverfasser: Kuroda, Junya, Ago, Tetsuro, Matsushima, Shouji, Zhai, Peiyong, Schneider, Michael D., Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932625/
https://ncbi.nlm.nih.gov/pubmed/20713697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002178107
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