NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

NAD(P)H oxidases (Noxs) produce O(2)(−) and play an important role in cardiovascular pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes. To elucidate the function of endogenous Nox4 in the heart, we generated cardiac-specific Nox4(−/−) (c-Nox4(−/−)) mice...

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Bibliographic Details
Main Authors: Kuroda, Junya, Ago, Tetsuro, Matsushima, Shouji, Zhai, Peiyong, Schneider, Michael D., Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932625/
https://ncbi.nlm.nih.gov/pubmed/20713697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002178107
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