Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

RATIONALE: Oxidation of cysteine residues in class II histone deacetylases (HDACs), including HDAC4, causes nuclear exit, thereby inducing cardiac hypertrophy. The cellular source of reactive oxygen species (ROS) responsible for oxidation of HDAC4 remains unknown. OBJECTIVE: We investigated whether...

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Bibliographic Details
Main Authors: Matsushima, Shouji, Kuroda, Junya, Ago, Tetsuro, Zhai, Peiyong, Park, Ji Yeon, Xie, Lai-Hua, Tian, Bin, Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574183/
https://ncbi.nlm.nih.gov/pubmed/23271793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.279760
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