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NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
NAD(P)H oxidases (Noxs) produce O(2)(−) and play an important role in cardiovascular pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes. To elucidate the function of endogenous Nox4 in the heart, we generated cardiac-specific Nox4(−/−) (c-Nox4(−/−)) mice...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932625/ https://ncbi.nlm.nih.gov/pubmed/20713697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002178107 |
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