Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of HIF-1α and Upregulation of PPARα

RATIONALE: Nox2 and Nox4 are major components of the NADPH oxidase (Nox) family, which purposefully produce reactive oxidative species (ROS), namely O(2)(−) and H(2)O(2), in the heart. The isoform-specific contribution of Nox2 and Nox4 to ischemia/reperfusion (I/R) injury is poorly understood. OBJEC...

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Detalhes bibliográficos
Main Authors: Matsushima, Shouji, Kuroda, Junya, Ago, Tetsuro, Zhai, Peiyong, Ikeda, Yoshiyuki, Oka, Shinichi, Fong, Guo-Hua, Tian, Rong, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871171/
https://ncbi.nlm.nih.gov/pubmed/23476056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300171
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