CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis

Production of hypochlorous acid (HOCl) in neutrophils, a critical oxidant involved in bacterial killing, requires chloride anions. Because the primary defect of cystic fibrosis (CF) is the loss of chloride transport function of the CF transmembrane conductance regulator (CFTR), we hypothesized that...

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Main Authors: Painter, Richard G., Valentine, Vincent G., Lanson, Nicholas A., Leidal, Kevin, Zhang, Qiang, Lombard, Gisele, Thompson, Connie, Viswanathan, Anand, Nauseef, William M., Wang, Guangdi, Wang, Guoshun
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931333/
https://ncbi.nlm.nih.gov/pubmed/16922501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060490t
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