CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis

Production of hypochlorous acid (HOCl) in neutrophils, a critical oxidant involved in bacterial killing, requires chloride anions. Because the primary defect of cystic fibrosis (CF) is the loss of chloride transport function of the CF transmembrane conductance regulator (CFTR), we hypothesized that...

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Main Authors: Painter, Richard G., Valentine, Vincent G., Lanson, Nicholas A., Leidal, Kevin, Zhang, Qiang, Lombard, Gisele, Thompson, Connie, Viswanathan, Anand, Nauseef, William M., Wang, Guangdi, Wang, Guoshun
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931333/
https://ncbi.nlm.nih.gov/pubmed/16922501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060490t
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