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CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis

Production of hypochlorous acid (HOCl) in neutrophils, a critical oxidant involved in bacterial killing, requires chloride anions. Because the primary defect of cystic fibrosis (CF) is the loss of chloride transport function of the CF transmembrane conductance regulator (CFTR), we hypothesized that...

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書誌詳細
主要な著者: Painter, Richard G., Valentine, Vincent G., Lanson, Nicholas A., Leidal, Kevin, Zhang, Qiang, Lombard, Gisele, Thompson, Connie, Viswanathan, Anand, Nauseef, William M., Wang, Guangdi, Wang, Guoshun
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931333/
https://ncbi.nlm.nih.gov/pubmed/16922501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060490t
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