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Cystic Fibrosis Transmembrane Conductance Regulator Recruitment to Phagosomes in Neutrophils
Optimal microbicidal activity of human polymorphonuclear leukocytes (PMN) relies on the generation of toxic agents such as hypochlorous acid (HOCl) in phagosomes. HOCl formation requires H(2)O(2) produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion. Chlo...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
S. Karger AG
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3717385/ https://ncbi.nlm.nih.gov/pubmed/23486169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000346568 |
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