Design of a Non-glycosylated Outer Domain-derived HIV-1 gp120 Immunogen That Binds to CD4 and Induces Neutralizing Antibodies

The outer domain (OD) of the HIV-1 envelope glycoprotein gp120 is an important target for vaccine design as it contains a number of conserved epitopes, including a large fraction of the CD4 binding site. Attempts to design OD-based immunogens in the past have met with little success. We report the d...

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Detaylı Bibliyografya
Asıl Yazarlar: Bhattacharyya, Sanchari, Rajan, Roshan Elizabeth, Swarupa, Yalla, Rathore, Ujjwal, Verma, Anjali, Udaykumar, Ranga, Varadarajan, Raghavan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930709/
https://ncbi.nlm.nih.gov/pubmed/20558728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152272
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