Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies

Protein minimization is an attractive approach for designing vaccines against rapidly evolving pathogens such as human immunodeficiency virus, type 1 (HIV-1), because it can help in focusing the immune response toward conserved conformational epitopes present on complex targets. The outer domain (OD...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rathore, Ujjwal, Purwar, Mansi, Vignesh, Venkada Subramanian, Das, Raksha, Kumar, Aditya Arun, Bhattacharyya, Sanchari, Arendt, Heather, DeStefano, Joanne, Wilson, Aaron, Parks, Christopher, La Branche, Celia C., Montefiori, David C., Varadarajan, Raghavan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166733/
https://ncbi.nlm.nih.gov/pubmed/30093409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005006
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