Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles

The broadly neutralizing antibody against HIV-1, bl2, binds to the CD4 binding site (CD4bs) on the outer domain (OD) of the gp120 subunit of HIV-1 Env. We have previously reported the design of an E.coli expressed fragment of HIV-1 gp120, b122a, containing about 70% of the b12 epitope with the idea...

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Библиографические подробности
Опубликовано в: :Vaccine
Главные авторы: Purwar, Mansi, Pokorski, Jonathan K., Singh, Pranveer, Bhattacharyya, Sanchari, Arendt, Heather, DeStefano, Joanne, La Branche, Celia C., Montefiori, David C., Finn, M.G., Varadarajan, Raghavan
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364316/
https://ncbi.nlm.nih.gov/pubmed/30220462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.07.032
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