Design of an Escherichia coli Expressed HIV-1 gp120 Fragment Immunogen That Binds to b12 and Induces Broad and Potent Neutralizing Antibodies

b12, one of the few broadly neutralizing antibodies against HIV-1, binds to the CD4 binding site (CD4bs) on the gp120 subunit of HIV-1 Env. Two small fragments of HIV-1 gp120, b121a and b122a, which display about 70% of the b12 epitope and include solubility-enhancing mutations, were designed. Bacte...

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Detalhes bibliográficos
Main Authors: Bhattacharyya, Sanchari, Singh, Pranveer, Rathore, Ujjwal, Purwar, Mansi, Wagner, Denise, Arendt, Heather, DeStefano, Joanne, LaBranche, Celia C., Montefiori, David C., Phogat, Sanjay, Varadarajan, Raghavan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617282/
https://ncbi.nlm.nih.gov/pubmed/23430741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425959
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