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Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity

The gp120 subunit of the HIV-1 envelope (Env) protein is heavily glycosylated at ∼25 glycosylation sites, of which ∼7–8 are located in the V1/V2 and V3 variable loops and the others in the remaining core gp120 region. Glycans partially shield Env from recognition by the host immune system and also a...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Rathore, Ujjwal, Saha, Piyali, Kesavardhana, Sannula, Kumar, Aditya Arun, Datta, Rohini, Devanarayanan, Sivasankar, Das, Raksha, Mascola, John R., Varadarajan, Raghavan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473224/
https://ncbi.nlm.nih.gov/pubmed/28446609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788919
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