Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies

A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses. The trimeric envelope glycoprotein (Env) spikes on HIV-1 are known to contain multiple epitopes that are susceptible to bNAbs isolated from infected individuals. None...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kesavardhana, Sannula, Das, Raksha, Citron, Michael, Datta, Rohini, Ecto, Linda, Srilatha, Nonavinakere Seetharam, DiStefano, Daniel, Swoyer, Ryan, Joyce, Joseph G., Dutta, Somnath, LaBranche, Celia C., Montefiori, David C., Flynn, Jessica A., Varadarajan, Raghavan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217686/
https://ncbi.nlm.nih.gov/pubmed/27879316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725614
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