Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies

A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses. The trimeric envelope glycoprotein (Env) spikes on HIV-1 are known to contain multiple epitopes that are susceptible to bNAbs isolated from infected individuals. None...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Kesavardhana, Sannula, Das, Raksha, Citron, Michael, Datta, Rohini, Ecto, Linda, Srilatha, Nonavinakere Seetharam, DiStefano, Daniel, Swoyer, Ryan, Joyce, Joseph G., Dutta, Somnath, LaBranche, Celia C., Montefiori, David C., Flynn, Jessica A., Varadarajan, Raghavan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217686/
https://ncbi.nlm.nih.gov/pubmed/27879316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725614
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