Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization

Following ectodomain shedding by β-secretase, successive proteolytic cleavages within the transmembrane sequence (TMS) of the amyloid precursor protein (APP) catalyzed by γ-secretase result in the release of amyloid-β (Aβ) peptides of variable length. Aβ peptides with 42 amino acids appear to be the...

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Hlavní autoři: Richter, Luise, Munter, Lisa-Marie, Ness, Julia, Hildebrand, Peter W., Dasari, Muralidhar, Unterreitmeier, Stephanie, Bulic, Bruno, Beyermann, Michael, Gust, Ronald, Reif, Bernd, Weggen, Sascha, Langosch, Dieter, Multhaup, Gerd
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930477/
https://ncbi.nlm.nih.gov/pubmed/20679249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003026107
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