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Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles

Amyloid precursor protein (APP) metabolites (amyloid-β (Aβ) peptides) and Tau are the main components of senile plaques and neurofibrillary tangles, the two histopathological hallmarks of Alzheimer disease. Consequently, intense research has focused upon deciphering their physiological roles to unde...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Multhaup, Gerhard, Huber, Otmar, Buée, Luc, Galas, Marie-Christine
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583011/
https://ncbi.nlm.nih.gov/pubmed/26296890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R115.677211
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