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Posttranslational glutathiolation of aldose reductase (AKR1B1); a possible mechanism of protein recovery from S-nitrosylation

Nitric oxide (NO) is an important regulator of the catalytic activity of aldose reductase (AR). It reacts with the active site cysteines of AR and this reaction results in the formation of several kinetically distinct forms of the protein. The catalytic activity of AR is increased in the ischemic he...

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Hlavní autoři: Baba, Shahid Pervez, Wetzelberger, Karin, Hoetker, Joseph David, Bhatnagar, Aruni
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929757/
https://ncbi.nlm.nih.gov/pubmed/19061876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2008.11.007
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