Role of Nitric Oxide in Regulating Aldose Reductase Activation in the Ischemic Heart

Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the ischemic heart due to oxidation of its cysteine residues, but the underlying mechanisms remain unclear. To examine signaling mechanisms regul...

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Bibliographic Details
Main Authors: Kaiserova, Karin, Tang, Xian-Liang, Srivastava, Sanjay, Bhatnagar, Aruni
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431016/
https://ncbi.nlm.nih.gov/pubmed/18223294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709671200
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