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Contribution of Aldose Reductase to Diabetic Hyperproliferation of Vascular Smooth Muscle Cells

The objective of this study was to determine whether the polyol pathway enzyme aldose reductase mediates diabetes abnormalities in vascular smooth muscle cell (SMC) growth. Aldose reductase inhibitors (tolrestat or sorbinil) or antisense aldose reductase mRNA prevented hyperproliferation of cultured...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Srivastava, Sanjay, Ramana, Kota V., Tammali, Ravinder, Srivastava, Satish K., Bhatnagar, Aruni
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463958/
https://ncbi.nlm.nih.gov/pubmed/16567509
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