γ-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice

Atherosclerosis is a chronic inflammatory disease resulting from interactions between lipids, macrophages and arterial wall cells. The Notch signaling pathway is involved in the activation of macrophages in atherosclerotic lesions. This study examined whether pharmacological inhibition of Notch sign...

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Hauptverfasser: Aoyama, Toru, Takeshita, Kyosuke, Kikuchi, Ryosuke, Yamamoto, Koji, Cheng, Xian Wu, Liao, James K., Murohara, Toyoaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929363/
https://ncbi.nlm.nih.gov/pubmed/19345673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.03.154
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