Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF

Notch signaling is reported to regulate angiogenesis, interacting with vascular endothelial growth factor (VEGF) signaling. HMG CoA reductase inhibitors (statins) also alter Notch signaling in vascular cells, but the mechanism and involvement of Notch and VEGF signaling in statin-mediated angiogenes...

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Bibliographische Detailangaben
Hauptverfasser: Kikuchi, Ryosuke, Takeshita, Kyosuke, Uchida, Yasuhiro, Kondo, Megumi, Cheng, Xian Wu, Nakayama, Takayuki, Yamamoto, Koji, Matsushita, Tadashi, Liao, James K, Murohara, Toyoaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807100/
https://ncbi.nlm.nih.gov/pubmed/21301413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.5
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