Regulation of DNA Repair through De-SUMOylation and SUMOylation of Replication Protein A Complex

The replication protein A complex (RPA) plays a crucial role in DNA replication and damage response. However, it is not known whether this complex is regulated by the SUMOylation pathway. Here we show that the 70kd subunit of RPA (RPA70) associates with a Sentrin/SUMO-specific protease, SENP6, in th...

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Main Authors: Dou, Hong, Huang, Chao, Singh, Melissa, Carpenter, Phillip B, Yeh, Edward T. H.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928994/
https://ncbi.nlm.nih.gov/pubmed/20705237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.021
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