Topoisomerase IIα maintains genomic stability through decatenation G(2) checkpoint signaling

Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry due to in...

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Hauptverfasser: Bower, Jacquelyn J., Karaca, Gamze F., Zhou, Yingchun, Simpson, Dennis A., Cordeiro-Stone, Marila, Kaufmann, William K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928865/
https://ncbi.nlm.nih.gov/pubmed/20562910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.232
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