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Topoisomerase IIα maintains genomic stability through decatenation G(2) checkpoint signaling
Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry due to in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928865/ https://ncbi.nlm.nih.gov/pubmed/20562910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.232 |
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