Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3

Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway. It contains multiple ubiquitin binding sites through which it anchors polyubiquitin chains of different link...

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Main Authors: Nicastro, Giuseppe, Todi, Sokol V., Karaca, Ezgi, Bonvin, Alexandre M. J. J., Paulson, Henry L., Pastore, Annalisa
格式: Artigo
語言:Inglês
出版: Public Library of Science 2010
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928749/
https://ncbi.nlm.nih.gov/pubmed/20865150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012430
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