The Josephin Domain Determines the Morphological and Mechanical Properties of Ataxin-3 Fibrils

Fibrillar aggregation of the protein ataxin-3 is linked to the inherited neurodegenerative disorder Spinocerebellar ataxia type 3, a member of the polyQ expansion disease family. We previously reported that aggregation and stability of the nonpathological form of ataxin-3, carrying an unexpanded pol...

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Detalhes bibliográficos
Main Authors: Masino, Laura, Nicastro, Giuseppe, De Simone, Alfonso, Calder, Lesley, Molloy, Justin, Pastore, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077691/
https://ncbi.nlm.nih.gov/pubmed/21504740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.02.056
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