Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3

As for a variety of other molecular recognition processes, conformational fluctuations play an important role in the cleavage of polyubiquitin chains by the Josephin domain of ataxin-3. The interaction between Josephin and ubiquitin appears to be mediated by the motions of α-helical hairpin that is...

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Publicat a:Biophys J
Autors principals: Sanfelice, Domenico, De Simone, Alfonso, Cavalli, Andrea, Faggiano, Serena, Vendruscolo, Michele, Pastore, Annalisa
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2014
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269769/
https://ncbi.nlm.nih.gov/pubmed/25517158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.008
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