Self-Assembly and Conformational Heterogeneity of the AXH Domain of Ataxin-1: An Unusual Example of a Chameleon Fold

Ataxin-1 is a human protein responsible for spinocerebellar ataxia type 1, a hereditary disease associated with protein aggregation and misfolding. Essential for ataxin-1 aggregation is the anomalous expansion of a polyglutamine tract near the protein N-terminus, but the sequence-wise distant AXH do...

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Detalhes bibliográficos
Main Authors: de Chiara, Cesira, Rees, Martin, Menon, Raj P., Pauwels, Kris, Lawrence, Ceri, Konarev, Petr V., Svergun, Dmitri I., Martin, Stephen R., Chen, Yu Wai, Pastore, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602761/
https://ncbi.nlm.nih.gov/pubmed/23528090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.01.048
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