MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

MDM2 is a key regulator of the p53 tumor suppressor acting primarily as an E3 ubiquitin ligase to promote its degradation. MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressors to p53. Here, we show that immunopurified MDM2 complexes have significant hist...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Chen, Lihong, Li, Zhenyu, Zwolinska, Aleksandra K, Smith, Matthew A, Cross, Brittany, Koomen, John, Yuan, Zhi-Min, Jenuwein, Thomas, Marine, Jean-Christophe, Wright, Kenneth L, Chen, Jiandong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928696/
https://ncbi.nlm.nih.gov/pubmed/20588255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.140
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky