MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

MDM2 is a key regulator of the p53 tumor suppressor acting primarily as an E3 ubiquitin ligase to promote its degradation. MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressors to p53. Here, we show that immunopurified MDM2 complexes have significant hist...

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Bibliografiske detaljer
Main Authors: Chen, Lihong, Li, Zhenyu, Zwolinska, Aleksandra K, Smith, Matthew A, Cross, Brittany, Koomen, John, Yuan, Zhi-Min, Jenuwein, Thomas, Marine, Jean-Christophe, Wright, Kenneth L, Chen, Jiandong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928696/
https://ncbi.nlm.nih.gov/pubmed/20588255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.140
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