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Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway
The mammalian target of rapamycin (mTOR) assembles into two distinct multiprotein complexes known as mTORC1 and mTORC2. Of the two complexes, mTORC1 acts to integrate a variety of positive and negative signals to downstream targets that regulate cell growth. The lipid second messenger, phosphatidic...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928642/ https://ncbi.nlm.nih.gov/pubmed/20427710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00039.2010 |
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