Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

The mammalian target of rapamycin (mTOR) assembles into two distinct multiprotein complexes known as mTORC1 and mTORC2. Of the two complexes, mTORC1 acts to integrate a variety of positive and negative signals to downstream targets that regulate cell growth. The lipid second messenger, phosphatidic...

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Bibliographic Details
Main Authors: Winter, Jeremiah N., Fox, Todd E., Kester, Mark, Jefferson, Leonard S., Kimball, Scot R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Receptors and Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928642/
https://ncbi.nlm.nih.gov/pubmed/20427710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00039.2010
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