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Hydrogen Peroxide Impairs Insulin-Stimulated Assembly of mTORC1

Oxidants are well-recognized for their capacity to reduce the phosphorylation of the mammalian target of rapamycin (mTOR) substrates, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and p70 S6 kinase 1 (S6K1), thereby hindering mRNA translation at the level of initiation. mTOR functions t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Shenberger, Jeffrey S., Zhang, Lianqin, Kimball, Scot R., Jefferson, Leonard S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677139/
https://ncbi.nlm.nih.gov/pubmed/19281842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.03.001
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