Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

The integrated stress response (ISR) protects cells from numerous forms of stress and is involved in the growth of solid tumours; however, it is unclear how the ISR acts on cellular proliferation. We have developed a model of ISR signalling with which to study its effects on tissue growth. Overexpre...

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Main Authors: Malzer, Elke, Daly, Marie-Louise, Moloney, Aileen, Sendall, Timothy J., Thomas, Sally E., Ryder, Edward, Ryoo, Hyung Don, Crowther, Damian C., Lomas, David A., Marciniak, Stefan J.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2010
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923568/
https://ncbi.nlm.nih.gov/pubmed/20682638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.070078
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